Table 1.

Participant characteristics.

	HC (n = 42) Mean ± SD or n (%)	PMDD (n = 89) Mean ± SD or n (%)
Age (years)	28 ± 6	33 ± 7*
BMI	23.8 ± 3.8	24.1 ± 4.0
TIV (L)	1.52 ± 0.11	1.50 ± 0.10
Menstrual cycle length (days)	28 ± 2	28 ± 2
PMDD duration (years)a	–	11 ± 7
Psychiatric history	7 (16.6%)	34 (38.2%)*
Depressive disorder	6 (85.7%)	27 (79.4%)
Anxiety disorder	1 (14.3%)	6 (17.6%)
Eating disorder	0	4 (11.8%)
Oestradiol (pmol/L)	434.5 ± 47.4	411.1 ± 239.8
Progesterone (nmol/L)	18.7 ± 15.0	21.9 ± 15.3
Luteal phase scanning day	−4 ± 2	−4 ± 3
Total DRSP score	38.6 ± 13.9	61.8 ± 18.2*

Differences between the groups were assessed using Mann–Whitney test for continuous variables, and Fischer Exact test for categorical variables.

BMI body mass index, DRSP daily record of severity of problems, SD standard deviation, TIV total intracranial volume, PMDD premenstrual dysphoric disorder, HC healthy controls.

*Significant group difference at p < 0.05.

^aData only available for a subset of 58 women with PMDD.