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. 2022 Jun 15;12:9961. doi: 10.1038/s41598-022-14000-8

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Heatmap showing the dyssynchrony index and the VCG-based time integral of voltage as well as speed for different conduction patterns in a heterogeneous population (local BH database). Each dot represents one patient, the blue line is the linear fit for the control population (Fig. 2) and dashed lines contain the 95% confidence interval (CI). Colorbar represent the value of the dyssynchrony index. Each patient was classified in its conduction pattern category by two cardiologists. Speed time integral (STI) vs. voltage time integral (VTI) plot for ECGs classified as normal conduction (a, n = 1672), incomplete right bundle branch block (IRBBB, b, n = 63), left anterior/left posterior fascicular flock (LAFB/LPFB, c, n = 78), complete right bundle branch block (RBBB, d, n = 47), right bundle branch block plus left anterior fascicular block (RBBB + LAFB, e, n = 22), incomplete left bundle branch block (ILBBB, f, n = 9), complete left bundle branch block (LBBB, g, n = 12) and pacemaker/cardiac resynchronization therapy (PM/CRT, h, n = 11). The figure was created using MATLAB R2019b (https://www.mathworks.com/).