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. 2022 Jun 2;12:921667. doi: 10.3389/fonc.2022.921667

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Copyright © 2022 Zhang, Numata, Du and Maeda

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Images of a man in his sixties with a pathological diagnosis of poorly to moderately differentiated hepatocellular carcinoma (HCC) and had a history of cirrhosis. At the Sonazoid-enhanced ultrasound (US), the liver lesion was heterogeneous hyperechoic with the indistinct margin on B-mode US (A). It was rapidly enhanced in the arterial phase (wash-in) (B), still iso-echoic in portal phase (C), and was totally exhausted in the post-vascular phase (D). At Gd-EOB-DTPA-enhanced MRI, the lesion was hypointense on T1-weighted image (F), with uncharacteristic wash-in and delayed wash-out from arterial phase to delayed phase (G, H). It showed hyperintensity on T2-weighted image (I). The contrast media (CM) were totally exhausted till the hepatobiliary phase (J). The gross specimen indicated the heterogeneous pathological differentiation of HCC (E). Arrowheads indicate the margin of the HCC lesion.