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. 2022 Jun 2;16:885569. doi: 10.3389/fncel.2022.885569

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Copyright © 2022 Liu, Mai, Yang, Jia, Chu, He, Fan and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mechanical thresholds and c-Fos expression in STN following CFA injection. (A) Changes in mechanical thresholds of mice before and 7 days after CFA injection. Mean ± SD, n = 6, **P < 0.01, ***P < 0.001, ****P < 0.0001. Data were analyzed by repeated measures ANOVA. (B) The c-Fos expression alteration in STN under normal and orofacial inflammatory pain conditions. Compared with normal group, the expression level of c-Fos protein in experimental group was significantly increased at 7 days after CFA injection. The blue fluorescence represents DAPI while red fluorescence represents c-Fos. Data were analyzed by unpaired t-test. ***P < 0.001, Scale bar = 300 μm. STN, spinal trigeminal nucleus; CFA, complete Freund’s adjuvant.