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. 2022 Jun 15;12:9919. doi: 10.1038/s41598-022-12980-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Mean postoperative GH nadir 24-48hrs after surgical resection in acromegaly cohort (n=26) (B) Preoperative and postoperative (3-12 months) IGF-1 levels in acromegaly cohort (n=25), two-tailed unpaired t-test demonstrates statistically significance between preoperative and postoperative IGF-1 levels (p<0.0001) (C) A graphical visual summary of the important findings from Table 1, 2 and 3 and demonstrates that somatotroph adenomas have a predilection to invade the cavernous sinus irrespective of tumor size. Using a Chi square test, we demonstrate that the effect that somatotrophs have on predicting cavernous sinus invasion was present across all Knosp grades 0-4 (*p<0.02) and even present across low Knosp grades 0-2 (**p<.05).