FIGURE 1.

Glycolytic response of the Ins2^Akita diabetic retina. (A–D) Seahorse glycolysis stress test conducted on retina explants from 7 months old WT and diabetic Akita mice shows a significant reduction in glycolysis and glycolytic capacity, but not glycolytic reserve in the diabetic retina as indicated by decreases in the extracellular acidification rate (ECAR) compared to the WT controls. *p < 0.05 vs. WT. N = 11. (E–H) Seahorse glycolysis stress test conducted on diabetic 14-months old retina explants show similar ECAR responses to age-matched WT retinas as presented by similar glycolysis, glycolytic capacity and glycolytic reserve. N = 11.