Skip to main content
. 2022 Jun 2;9:900640. doi: 10.3389/fcvm.2022.900640

FIGURE 3.

FIGURE 3

Mitochondrial respiration of the Ins2Akita diabetic retina. (A–E) Seahorse mitochondria stress test conducted by measuring the oxygen consumption rate (OCR) in retinal explants from 7-month-old mice shows no changes in basal respiration, maximal respiration, spare respiratory capacity and ATP production compared to control. N = 4. (G–K) Seahorse mitochondria stress test conducted by measuring the oxygen consumption rate (OCR) in retinal explants from 14-month-old mice shows no changes in basal respiration, maximal respiration, spare respiratory capacity and ATP production compared to control. N = 10–12. (F,L) Basal respiration calculated from the glycolysis assay analyses under no glucose conditions shows a reduction in basal OCR in the diabetic retinas from both 7- and 14-month-old Akita mice. *p < 0.05 vs. WT. N = 11.