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. 2022 Jun 2;9:829033. doi: 10.3389/fmed.2022.829033

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Copyright © 2022 Liu, Xiao, Xia, Huang, Chen, Xu, Chen, Wang, Wei, Li, Shu, Lu, Zhang and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images and drug tests of the organoids. (A) Dose-response curves of organoids treated with 5-FU, oxaliplatin, SN38, apatinib, dasatinib, docetaxel, regorafenib and everolimus. (B) Mean ± SD of results from three independent experiments is shown for each drug. (C) Representative images of the organoid after treatment with 1 μM SN38 and DMSO. Organoid treated with 1 μM apatinib and DMSO. Scale bar = 200 μm.