Table 1.
PARK categories from the genes related to PD.
| Locus (OMIM #) | Location | HUGO gene name | Gene symbol | Disease onset | Inheritance | LB pathology | Genes appeared by GWAS |
|---|---|---|---|---|---|---|---|
| PARK1 (163890) | 4q22.1 | Synuclein alpha | SNCA | Young- or middle-aged onset | AD | +++ | + |
| PARK2 (602544) | 6q26 | Parkin RBR E3 ubiquitin-protein ligase | PRKN | Young- or juvenile-onset | AR | – | |
| PARK3 (NA) | 2p13 | PARK3 | Late-onset | AD | |||
| PARK4 (163890) = PARK1 | 4q22.1 | Synuclein alpha | SNCA | Young- or middle-aged onset | AD | +++ | + |
| PARK5 (191342) | 4p13 | Ubiquitin C-terminal hydrolase L1 | UCHL1 | Young- or middle-aged onset | AD | ||
| PARK6 (608309) | 1p36 | PTEN induced kinase 1 | PINK1 | Young-onset | AR | – | |
| PARK7 (602533) | 1p36.23 | Parkinsonism associated deglycase | PARK7 | Young-onset | AR | ||
| PARK8 (609007) | 12q12 | Leucine-rich repeat kinase 2 | LRRK2 | Late-onset | AD | –, + or +++ | + |
| PARK9 (610513) | 1p36.13 | ATPase cation transporting 13A2 | ATP13A2 | Young-onset | AR | – | |
| PARK10 (NA) | 1p32 | Parkinson disease 10 (susceptibility) | PARK10 | Late-onset | Unclear | ||
| PARK11 (612003) | 2q37.1 | GRB10 interacting GYF protein 2 | GIGYF2 | Late-onset | AD | ||
| PARK12 (NA) | Xq21-q25 | Parkinson disease 12 (susceptibility) | PARK12 | Late-onset | X-linked | ||
| PARK13 (606441) | 2p13.1 | HtrA serine peptidase 2 | HTRA2 | Young- and late-onset | AD | ||
| PARK14 (603604) | 22q13.1 | Phospholipase A2 group VI | PLA2G6 | Young-onset | AR | ||
| PARK15 (605648) | 22q12.3 | F-box protein 7 | FBXO7 | Young-onset | AR | ||
| PARK16 (NA) | 1q32 | Parkinson disease 16 (susceptibility) | PARK16 | Late-onset | Unclear | ||
| PARK17 (601501) | 16q11.2 | VPS35 retromer complex component | VPS35 | Late-onset | AD | ||
| PARK18 (600495) | 3q27.1 | Eukaryotic translation initiation factor 4 gamma 1 | EIF4G1 | Late-onset | AD | ||
| PARK19 (608375) | 1p31.3 | DnaJ heat shock protein family (Hsp40) member C6 | DNAJC6 | Young-onset | AR | ||
| PARK20 (604297) | 21q22.1 | Synaptojanin 1 | SYNJ1 | Young-onset | AR | ||
| PARK21 (614334) | 20p13 | DnaJ heat shock protein family (Hsp40) member C13 | DNAJC13 | Late-onset | AD | ||
| PARK22 (616244) | 7p11.2 | Coiled-coil-helix-coiled-coil-helix domain containing 2 | CHCHD2 | Late-onset | AD | +++ | |
| PARK23 (608879) | 15q22.2 | Vacuolar protein sorting 13 homolog C | VPS13C | Young-onset | AR | +++ | + |
| PARK24 (176801) | 10q22.1 | Prosaposin | PSAP | Middle- or late-onset | AD | ||
| Non-categorized genes in PARK | |||||||
| (600225) | 14q22.2 | GTP cyclohydrolase 1 | GCH1 | Young-onset | AD | – | + |
| (606463) | 1q22 | Glucosylceramidase beta | GBA1 | Young-onset | AR | +++ | + |
| (NA) | 5q34 | ATPase phospholipid transporting 10B (putative) | ATP10B | Young-onset | AR | ||
OMIM, Online Mendelian Inheritance in Man; HUGO, human genome organization; AD, autosomal dominant; AR, autosomal recessive; NA, not applicable.