TABLE 4.
Reported evidence of increasing sensitization.
| Herb | Evidence | Dosage of tamoxifen | Dosage of herb | Effects | Suggested mechanism |
|---|---|---|---|---|---|
| Z-Ligustilide | MCF-7 TR5 cell lines (Qi et al., 2017) | 2.5 μM | 50 μM | Induce autophagy and apoptosis | Restore autophagy-degrades Nur77 |
| Curcumin | MCF-7/LCC2 cell lines (Jiang et al., 2013) | 2.5 μM | 1.78 μM | Increase sensitivity to 4-OHT | - |
| MCF-7/LCC9 cell lines (Jiang et al., 2013) | 4.09 μM | ||||
| Antrodia cinnamomea extract | MCF-7/Tam-R (Lin et al., 2018) | 10 μM | 100, 150, 200 ug/ml | Inhibit cell proliferation | - |
| Evn-50 | MCF-7/Tam-R (Hu et al., 2012) | 5 μmol/L | 50 μg/ml | Inhibit cell viability, induce apoptosis and G2 phases cell cycle arrest | Downregulate AKT and MAPK pathway |
| Persin | MCF-7/Tam-R (McCloy et al., 2013) | 7.5 μM | 1 μg/ml | Reverses 4-OHT resistance, induce apoptosis | Mediate ERS signal |
| JEKHT a | MCF-7/LCC9 cell lines (De Oliveira Andrade et al., 2019) | 125 nM | 1 mg/ml | Inhibit cell proliferation | - |
a
JEKHT: composed of Paeonia (Paeonia lactiflora Pall.), Korean angelica root (Angelica gigas Nakai), Asparagi Tuber (Asparagus cochinchinensis (Lour.) Merr.), White atractylis (Atractylodes lancea (Thunb.) DC.), R. glutinosa (Rehmannia glutinosa (Gaertn.) DC.), Dried orange peel (Citrus aurantium L.), Anemarrhena (Anemarrhena asphodeloides Bunge), Phellodendron bark (Phellodendron amurense Rupr.), Licorice (Glycyrrhiza glabra L.), Ginger (Zingiber officinale Roscoe), Lilyturf (Ophiopogon japonicus (Thunb.) Ker Gawl.), Jujube (Ziziphus jujuba Mill.)