FIGURE 4.

Nanotechnology enhances radiotherapy in NB. (A–B) The tumor hypoxic microenvironment was modulated using perfluorocarbon nanoparticles as an oxygen shuttle, which significantly improved the therapeutic effect of PDT and RT on tumors. Reproduced with permission from: Xuejiao Song, Liangzhu Feng, Chao Liang, Kai Yang, and Zhuang Liu. Ultrasound triggered tumor oxygenation with oxygen-shuttle nanoperfluorocarbon to overcome hypoxia-associated resistance in cancer therapies. Nano letters, 2016, 16(10): 6145–6153 (Song et al., 2016). Copyright 2016, American Chemical Society. (C–D) Schematic diagram of MIBG and DOPAC-coated Fe3O4@TiO2 as potential radiosensitizers for NB. Reproduced with permission (Liu et al., 2021). Copyright 2021, Springer Nature.