TABLE 2.

Summary of emerging nanomedicines for NB chemotherapy.

Formulation	Type of NPs	Drug	Model	Observed effects	Ref.
CPT/HP-β-CD and CPT/β-CD	Cyclodextrin	CPT	In vitro	Enhanced the bioactivity and antitumor activity of the CPT	González-Ruiz et al. (2021)
LP-2- pyrazolo[3,4-d]pyrimidines	Liposome	Pyrazolo[3,4-d]pyrimidines	In vitro	Exhibited inhibitory activity against NB cell	Vignaroli et al. (2016)
ApoE3-C-PBCA- Curcumin	ApoE3-C-PBCA	Curcumin	In vitro	Enhanced anticancer activity of curcumin against NB cell	Mulik et al. (2012)
Nab-PTX	Nab	PTX	In vitro and in vivo	Inhibited NB cells growth and prolongs the survival of tumor-bearing mice	Zhang et al. (2013)
PLGA-PTX	PLGA	PTX	In vitro	Induced DNA damage in NB cells	Bacanlı et al. (2021)
Nab-PTX	Nab	PTX	phase I/II	Relatively safe for children with NB	(Moreno et al., 2018; Amoroso et al., 2020)