TABLE 3.

Summary of nanocomposite applications of potential targets available for NB diagnosis or therapy.

Target	Function	Formulations	Nanocarrier	Observed effects	Assays	Ref.
GD2	Promoted neural differentiation, repair, invasion and immunosuppression.	IGD-Targeted	DNA nanomedicine	Selective delivery of Dox to GD2-positive NB tumor cells	In vitro and in vivo	Zhang et al. (2021a)
		Self-assembly of aptamers DB99 and MYCN-siRNA and Dox	DNA nanomedicine	Specifically Knockdown of MYCN and release of Dox in GD2-positive NB cells	In vitro and in vivo	Zhang et al. (2021b)
		Gold NPs conjugated to anti-GD2 antibody HGNPs,	Gold NPs	Enhanced both CT imaging and NK cell-mediated cancer cell killing	In vitro	Jiao et al. (2016)
MYCN	Promoted tumorigenesis and malignant progression of NB	Folate-nanoliposome entrapped MYCN siRNA	Folate-nanoliposome	Pro-apoptotic effect	In vitro	Zhu et al. (2013)
ALK	Induced cellular overproliferation and the development of NB	TL-ALK-siRNA	Anti-GD2-targeted liposomes	Antitumor activity	In vitro and in vivo	Di Paolo et al. (2011)
VEGF	Angiogenesis and tumorigenesis of NB	SiO2@LDH-Bev-DOX	SiO2@LDH-Bev NPs	Antitumor and anti-angiogenesis efficiency	In vitro and in vivo	Zhu et al. (2017)
NCAM	Mediated tumor cell metastasis	PG-NTP-PTX-PEG	Dendritic polyglycerol	Inhibited the migration of proliferating endothelial cells	In vitro and in vivo	Vossen et al. (2018)
		PGA-PTX-NTP	Polyglutamic acid	Inhibited tumor growth	In vitro and in vivo	Markovsky et al. (2017)