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Dynamic changes of three different viral markers. (A) HBsAg declined significantly during the 48-week IFN switched therapy; (B) miR-3 declined significantly during 48 weeks of treatment, with little change from week 12 to 24; (C) pgRNA declined significantly through 48 weeks treatment, with little changes from weeks 12 to 24 and weeks 24 to 48. HBsAg, hepatitis B surface antigen; pgRNA, pregenomic RNA; IFN, interferon; ns, not statistically significant, P>0.05.
