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. 2022 May;10(10):594. doi: 10.21037/atm-22-1855

Figure 5.

Figure 5

MSC transplantation ameliorated SS in NOD mice. (A) MSCs reversed the pathological changes in the salivary gland, stained with H&E. (B) MSCs reversed the pathological changes in the lung, stained with H&E. (C) MSCs decreased salivary gland weight and increased saliva flow rate in NOD/Ltj mice. (D) The proportion and number of Vγ4+ T cells and Vγ4+ IL-17A+ T cells in the spleen of NOD/Ltj mice after MSC transplantation. (E) The proportion and number of Vγ4+ T cells and Vγ4+ IL-17A+ T cells in the lung of NOD/Ltj mice after MSC transplantation. (n=10, *, P<0.05; **, P<0.01; ***, P<0.001, ns, no significance). The black arrows indicate lymphocytic infiltration. The 150 µm scale stands for the whole staining image, while 50 µm scale stands for the small staining image with higher magnification to better see the inflammatory infiltration. SS, Sjögren’s syndrome; SG, salivary gland; NOD, non-obese diabetic; H&E, hematoxylin and eosin; PBS, phosphate-buffered saline; MSCs, mesenchymal stem cells.