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The expression of HIF-1α after treatment with Rh and AZ at normoxia and hypoxia. 0 h means the Rats were treated with normoxia and 5 h means the Rats were treated with hypoxia for 5 hours. The expression of HIF-1α was significantly increased under hypoxia. Rh and AZ inhibited this increase, and their combined use inhibited this increase more significant than alone use. *, P≤0.05. All data is presented mean ± SD. HIF, hypoxia-inducible factor; Rh, Rhodiola; AZ, acetazolamide.
