Table 1.
Clinical characteristics and outcome of patients (N = 123) with CRE superinfections
| Characteristics | Number (%), N=123 |
|---|---|
| Demographics | |
| Age, years, median (IQRs) | 66 (59–75) |
| Male sex | 95 (77.2) |
| Comorbidities | |
| Cardiovascular disease | 48 (39) |
| Cancer | 20 (16.3) |
| Diabetes mellitus | 29 (23.6) |
| COPD | 15 (12.2) |
| Chronic renal disease | 16 (13) |
| Charlson Comorbidity Score, median (IQR) | 3 (1–4) |
| Clinical features on admission | |
| PaO2/FiO2 ratio, median (IQR) | 172.5 (126–230) |
| Thrombocytopenia | 38 (30.9) |
| Lymphocytes < 0.8 × 109/L | 63 (51.2) |
| Treatments against COVID-19 | |
| Corticosteroids | 75 (60.9) |
| Remdesivir | 29 (23.6) |
| Immunomodulants | 33 (26.8) |
| Ward of hospitalization at time of CRE infection | |
| ICU | 81 (65.8) |
| Medical ward | 42 (34.1) |
| Oxygen support at time of CRE infection | |
| High flow nasal cannula | 3 (2.4) |
| Non-invasive ventilation | 12 (9.8) |
| Invasive mechanical ventilation | 68 (55.3) |
| CRE rectal colonizationa | 80/106 (75.5) |
| SOFA, median (IQR) at time of CRE infection | 7 (4–11) |
| Septic shock at time of CRE infection | 35 (28.5) |
| Pitt bacteraemia score at time of CRE infection, median (IQR) | 2 (2–4) |
| Days from admission to superinfection, median (IQR) | 16 (10–26) |
| Time from admission to superinfection, n (%) | |
| 3–14 days | 47 (38.2) |
| 15–30 days | 52 (42.3) |
| >30 days | 24 (19.5) |
| Length of hospital stay, days, median (IQR) | |
| From admission | 25.5 (16–41) |
| From infection | 15.5 (7–24.75) |
| All cause in-hospital mortality | 51 (41.5) |
| 30 day mortality | 41 (33.3) |
Abbreviations: ICU, intensive care unit; COPD, chronic obstructive pulmonary disease; CRE, carbapenem-resistant Enterobacterales; SOFA, sequential organ failure assessment.
a
Data on rectal colonization was available in 106/123 patients.