TABLE 2.

The neuroprotection of ginsenoside Rb1 in PD.

PD models	Dose of Rb1	Effects	Mechanisms	References
α-syn-treated BE(2)-M17 cells	5 μM	Restoring the decreased cell viability	Inhibiting α-syn fibrillation and toxicity	Ardah et al. (2015)
LPS-induced rat model	20 mg/kg for 14 consecutive days	Restoring DA and its metabolites in striatum and DA neurons degeneration in SN	Inactivating microglia in SN and inhibiting neuroinflammation	Da-Wei Li et al. (2019a)
MPTP-induced mouse model	40 mg/kg for 14 consecutive days	Ameliorating motor deficits, preventing DA neuron death	Attenuating glutamate excitotoxicity and modulating glutamatergic transmission pathways	Zhang et al. (2018)
MPTP-induced mouse model	10 mg/kg for 14 consecutive days	Mitigating MPTP-induced altered gait parameters and cognitive impairment	Regulating GABAergic transmission	Liu et al. (2019)
MPTP-induced mouse model	40 mg/kg for 14 consecutive days, starting 3 days before MPTP treatment	Improving memory deficiency	Improving synaptic plasticity	Qu et al. (2019)