Table 2.
Optimized cut-off values for FHA-PCOM.
| Parameter | Statistical method | Optimized cut-off value | Sensitivity (95%CI) | Specificity (95%CI) | PPV (95%CI) | NPV (95%CI) | p |
|---|---|---|---|---|---|---|---|
| Estradiol | Youden index | <37.5 pg/mL | 84.48 (72.58-92.65) | 82.76 (70.57-91.41) | 83.05 (73.39-89.69) | 84.21 (74.31-90.77) | <0.001 |
| Testosterone | Youden index | <0.31 ng/mL | 79.31 (66.65-88.83) | 86.21 (74.21-93.85) | 85.19 (74.89-91.73) | 80.65 (71.36-87.45) | <0.001 |
| SHBG | Youden index | >61.4 nmol/L | 68.97 (55.46-80.46) | 79.31 (66.65-88.83) | 76.92 (66.18-85.03) | 71.88 (63.01-79.31) | <0.001 |
| LH | Youden index | <4.7 mIU/mL | 74.14 (60.69-84.74) | 77.59 (64.73-87.49) | 76.79 (66.68-84.54) | 75.00 (65.51-82.57) | <0.001 |
| LH: FSH ratio | Youden index | <0.96 | 72.41 (59.10-83.34) | 94.83 (85.62-98.92) | 93.33 (82.14-97.71) | 77.46 (96.28-83.97) | <0.001 |
All data are provided as %; PPV, positive predictive value; NPV, negative predictive value.