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. 2022 Jun 16;87(6):524–537. doi: 10.1134/S0006297922060049

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© Pleiades Publishing, Ltd. 2022

This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.

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Fig. 3. — 25-HC targets in the nervous system. The main producers of 25-HC are activated macrophages and microglial cells [3, 4, 58]. Released 25-HC can affect glial cells (microglia, oligodendrocytes, astrocytes, and Schwann cells) and neurons. 25-HC influences synaptic transmission by acting on presynaptic and postsynaptic receptors (see the text for detailed explanation). Designations: DNMT, DNA methyltransferases; ERα, estrogen receptor α; Slo1 BK, large-conductance calcium-activated potassium channels.