TABLE 1.

Effect of in utero exposure to ethynil estradiol (EE2) or gensitein (GE) on perinatal development. Females were exposed by gavage from gestational day (GD) 13 to 19. Progeny was sacrificed on GD20 (n = 5 litters) or post-natal day 5 (PND5, n = 4 litters). Male and females were counted and weighted. Ano-genital distance was measured from anus to tip of genital tubercle and gonads were sampled and weighted. *p < 0.05 compared to control using a non-paired t-test.

		Ctrl	EE2	GE
	Maternal weight gain during treatment (g)	47.67 ± 1.58	41.00 ± 1.38*	43.89 ± 1.2
GD20	Number of live fetuses per litter	12.20 ± 0.86	12.00 ± 0.55	12.60 ± 0.51
	Male fetuses weight (g)	3.54 ± 0.10	3.52 ± 0.08	3.52 ± 0.06
	Female fetuses weight (g)	3.42 ± 0.07	3.44 ± 0.08	3.37 ± 0.07
	Anogenital distance males (mm)	4.13 ± 0.13	3.98 ± 0.14	3.91 ± 0.09
	Anogenital distance females (mm)	2.37 ± 0.12	2.27 ± 0.15	2.28 ± 0.07
	Testis weight (mg)	1.43 ± 0.05	1.48 ± 0.06	1.39 ± 0.05
	Ovary weight (mg)	0.21 ± 0.01	0.24 ± 0.05	0.21 ± 0.01
PND5	Number of live pups per litter	11.75 ± 0.63	10.75 ± 1.25	10.75 ± 0.48
	Male pups weight (g)	10.28 ± 0.32	10.15 ± 0.48	9.97 ± 0.39
	Female pups weight (g)	9.84 ± 0.29	9.72 ± 0.44	9.55 ± 0.37
	Anogenital distance males (mm)	6.64 ± 0.24	6.75 ± 0.33	6.51 ± 0.27
	Anogenital distance females (mm)	3.66 ± 0.13	3.57 ± 0.24	3.41 ± 0.16
	Testis weight (mg)	6.87 ± 0.24	7.03 ± 0.34	6.71 ± 0.12
	Ovary weight (mg)	0.48 ± 0.04	0.37 ± 0.04	0.36 ± 0.06