TABLE 1.
Demographic information and neuropsychological test results of MCI and CN subjects.
| Variables | Total (n = 939)1 | NC (n = 673)1 | MCI (n = 266)1 | p-value2 |
| Age (year) | 0.002 | |||
| Mean (SD) | 72.1 (6.3) | 71.7 (6.2) | 73.1 (6.5) | |
| Sex, n (%) | 0.188 | |||
| Female | 505 (53.8%) | 371 (55.1%) | 134 (50.4%) | |
| Male | 434 (46.2%) | 302 (44.9%) | 132 (49.6%) | |
| Education level (year) | 0.295 | |||
| Mean (SD) | 12.1 (4.6) | 12.0 (4.6) | 12.3 (4.4) | |
| Systolic BP (mmHg) | 0.634 | |||
| Mean (SD) | 124 (15) | 125 (14) | 124 (16) | |
| Diastolic BP (mmHg) | 0.736 | |||
| Mean (SD) | 71 (10) | 71 (10) | 71 (10) | |
| GDS score | 0.042 | |||
| Mean (SD) | 8.3 (6.9) | 8.0 (6.8) | 9.0 (7.0) | |
| K-MMSE score | <0.001 | |||
| Mean (SD) | 27.2 (2.2) | 27.6 (1.9) | 26.2 (2.5) | |
| Attention | <0.001 | |||
| Mean (SD) | 9.3 (2.2) | 9.7 (2.2) | 8.5 (1.8) | |
| Language | <0.001 | |||
| Mean (SD) | 0.2 (0.3) | 0.2 (0.3) | 0.0 (0.4) | |
| Visuospatial | <0.001 | |||
| Mean (SD) | 0.5 (0.4) | 0.5 (0.4) | 0.3 (0.6) | |
| Memory | <0.001 | |||
| Mean (SD) | 0.1 (0.7) | 0.3 (0.6) | −0.4 (0.6) | |
| Frontal | <0.001 | |||
| Mean (SD) | 0.1 (0.6) | 0.2 (0.6) | −0.2 (0.7) | |
| Diabetes, n (%) | 0.011 | |||
| Yes | 168 (17.9%) | 107 (15.9%) | 61 (22.9%) | |
| No | 771 (82.1%) | 566 (84.1%) | 205 (77.1%) | |
| Hypertension, n (%) | 0.574 | |||
| Yes | 403 (42.9%) | 285 (42.3%) | 118 (44.4%) | |
| No | 536 (57.1%) | 388 (57.7%) | 148 (55.6%) | |
| Hyperlipidemia, n (%) | 0.019 | |||
| Yes | 183 (19.5%) | 144 (21.4%) | 39 (14.7%) | |
| No | 756 (80.5%) | 529 (78.6%) | 227 (85.3%) | |
| Thyroid, n (%) | 0.692 | |||
| Yes | 32 (3.4%) | 22 (3.3%) | 10 (3.8%) | |
| No | 904 (96.6%) | 650 (96.7%) | 254 (96.2%) | |
| Mental disorder, n (%) | 0.627 | |||
| Yes | 21 (2.2%) | 14 (2.1%) | 7 (2.6%) | |
| No | 917 (97.8%) | 658 (97.9%) | 259 (97.4%) | |
| Circulatory disorder, n (%) | 0.525 | |||
| Yes | 151 (16.1%) | 105 (15.6%) | 46 (17.3%) | |
| No | 788 (83.9%) | 568 (84.4%) | 220 (82.7%) | |
| CNS disorder, n (%) | 0.024 | |||
| Yes | 5 (0.5%) | 1 (0.1%) | 4 (1.5%) | |
| No | 932 (99.5%) | 671 (99.9%) | 261 (98.5%) | |
| Cohabitation, n (%) | 0.624 | |||
| Single | 126 (13.4%) | 88 (13.1%) | 38 (14.3%) | |
| With family | 813 (86.6%) | 585 (86.9%) | 228 (85.7%) | |
| Dominant hand, n (%) | 0.049 | |||
| Righty | 911 (97.0%) | 655 (97.3%) | 256 (96.2%) | |
| Lefty | 7 (0.7%) | 2 (0.3%) | 5 (1.9%) | |
| Both | 21 (2.2%) | 16 (2.4%) | 5 (1.9%) |
1The values represent mean (SD) for continuous variables, and n (%) for categorical variables. The p-values for the continuous variables were obtained from an independent two sample t-test for normally distributed variables or Mann–Whitney–Wilcoxon rank sum test for non-normally distributed variables. For the categorical variables, the p-values were derived from the Chi-squared test statistics or Fisher-exact test. CNS, central nervous system.
2Wilcoxon rank sum test; Pearson’s Chi-squared test; two sample t-test; Fisher’s exact test. The bold fonts indicate a p-value lower than 0.05.