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. 2022 Jun 2;10:903179. doi: 10.3389/fcell.2022.903179

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Copyright © 2022 Qu, Li, Wang, Zhao, Wu, Liu, Hong, Yang, Shu and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Enriched environment exposure leads to the altered transcriptome. (A) Heatmap illustrating the altered transcriptome in EE mice compared to SH mice. Red color, up-regulated genes; blue color, down-regulated genes. Three biological repeating brain samples of SH and EE mice were adopted for sequencing. (B) GO analysis of the up- and down-regulated genes revealed enrichment for biological process terms related to synapse organization, axon development, learning, and memory. (C,D) GO cell component (GO_CC) (C) and GO molecular function (GO_MF) enrichment analysis showed that differential expressed genes (DEGs) involve in synapse activity, especially GABAergic synapse. (E) Violin plots showed that up-regulated genes in the EE group significantly enriched in the indicated GO terms compared to the SH group. *p < 0.05; **p < 0.01; ***p < 0.001; unpaired Students t-test. (F) Twenty-three genes in the MANGO database were revealed by our RNA-seq. Seven genes, six up- and one down-regulated, exhibited altered expression. (G) The interaction analysis showed up-regulated genes related to neuronal development (green), learning and memory (red), and synapse organization (purple).