Table 2.
Baseline characteristics of all patients with CLL and those in the IGH-t (IGH-BCL2, IGH-BCL3, IGH-others) and non-IGH-t groups.
| All patients (n=138) | IGH-t (n=25) | non-IGH-t (n=113) | IGH-t vsnon-IGH-t (P-value) | |||
|---|---|---|---|---|---|---|
| IGH-BCL2 (n=10) | IGH-BCL3(n=3) | IGH-others (n=12) | ||||
| Median age (range, years) | 61 (27–84) | 61 (46–77) | 54 (46–56) | 62 (40–75) | 61 (27–84) | 0.619 |
| Male | 96 | 8 | 3 | 9 | 76 | 0.311 |
| Rai stage | 0.198 | |||||
| 0–II | 64 | 7 | 1 | 7 | 49 | |
| III–IV | 74 | 3 | 2 | 5 | 64 | |
| Binet stage | 0.690 | |||||
| A | 43 | 5 | 0 | 3 | 35 | |
| B | 36 | 3 | 2 | 3 | 28 | |
| C | 59 | 2 | 1 | 6 | 50 | |
| Elevated β2 MG | 37 | 2 | 2 | 4 | 29 | 0.691 |
| Flow score | 0.032 | |||||
| 3 | 37 | 1 | 2 | 8 | 26 | |
| ≥4 | 101 | 9 | 1 | 4 | 87 | |
| Unmutated-IGHV | 29 | 0 | 3 | 2 | 24 | 0.362 |
| IGHV-ND | 35 | 1 | 0 | 0 | 34 | |
| CK | 22 | 0 | 2 | 3 | 17 | 0.540 |
CLL, Chronic lymphocytic lymphoma; IGH, immunoglobulin heavy chain gene; FISH, fluorescence in situ hybridization; IGHV, immunoglobulin heavy variable; g2 MG, β2-microglobulin; ND, data not done; CK, complex karyotype.