Table 1.
Patient characteristics
Factor | Number of patients / Mean ± standard deviation |
p value | |||
---|---|---|---|---|---|
Total | Oral cancer | Oropharyngeal cancer | |||
Age (years) | 65.8 ± 11.6 | 66.0 ± 12.5 | 65.3 ± 9.67 | 0.582 | |
Sex | Female | 94 | 80 | 14 | <0.001 |
Male | 272 | 162 | 110 | ||
Diabetes | (−) | 301 | 195 | 106 | 0.312 |
(+) | 65 | 47 | 18 | ||
Leukocytes | 2969 ± 1234 | 3056 ± 1295 | 2800 ± 1092 | 0.060 | |
Lymphocytes | 441 ± 310 | 488 ± 325 | 351 ± 258 | <0.001 | |
Creatinine | 0.877 ± 0.736 | 0.803 ± 0.678 | 1.02 ± 0.822 | 0.007 | |
Albumin | 3.64 ± 0.537 | 3.67 ± 0.516 | 3.57 ± 0.571 | 0.086 | |
Total dose | 64.3 ± 5.13 | 62.7 ± 4.95 | 67.6 ± 3.79 | <0.001 | |
Neck dissection before RT | (−) | 138 | 45 | 93 | <0.001 |
(+) | 228 | 197 | 31 | ||
RT method | 3D-CRT | 277 | 211 | 66 | <0.001 |
IMRT | 89 | 31 | 58 | ||
Concurrent therapy | RT alone | 115 | 98 | 17 | <0.001 |
CRT | 214 | 133 | 81 | ||
BRT | 37 | 11 | 26 | ||
Remaining teeth | (−) | 26 | 19 | 7 | 0.523 |
(+) | 340 | 223 | 117 | ||
Alveolar bone loss | 50% or less | 231 | 163 | 68 | 0.022 |
more than 50% | 135 | 79 | 56 | ||
Periapical lesion at the start of RT | (−) | 310 | 206 | 104 | 0.761 |
(+) | 56 | 36 | 20 | ||
Severe periodontal disease at the start of RT | (−) | 334 | 218 | 116 | 0.330 |
(+) | 32 | 24 | 8 | ||
Tooth extraction before RT | (−) | 215 | 151 | 64 | 0.056 |
(+) | 151 | 91 | 60 | ||
Tooth extraction after RT | (−) | 332 | 221 | 111 | 0.573 |
(+) | 34 | 21 | 13 | ||
Total | 366 | 242 | 124 |
Abbreviations: 3D-CRT: three dimensional conformal radiotherapy; BRT: bio-radiotherapy; CRT: chemo-radiotherapy; IMRT: intensity modulated radiotherapy; RT: radiotherapy.