Figure 2.

Hierarchical organization of amyloid fibrils. The dominant components of amyloid plaques or deposits are amyloid fibrils (A,B), which are formed by close lateral association of protofilaments (C). In turn, protofilaments are formed by stacking of monomeric subunits, and usually consist of a single stack (D). The density map obtained by Mizuno et al. (2011) was used as a template for the fibril schematic in part (B).