Table 3.
Breast cancer riska and exposure to urinary BPA, triclosan, and total parabens by body mass index (BMI) and waist hip ratio (WHR), using nested case-control data from the Multiethnic Cohort Study (1993–2014)
| BMI at urine collection | All cases/controls with WHR ORa (95% CI | WHR at urine collectionb | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤25 kg/m2 | >25 kg/m2 | ≤0.854 | >0.854 | ||||||||||
| Case | Control | ORa (95% CI) | Case | Control | OR (95% CI) | Case | Control | ORa (95% CI) | Case | Control | OR (95% CI) | ||
| BPA | |||||||||||||
| ≤ 0.84 | 141 | 172 | 1.00 | 231 | 178 | 1.00 | 1.00 | 40 | 158 | 1.00 | 43 | 165 | 1.00 |
| 0.84– ≤1.76 | 119 | 184 | 0.77 (0.56–1.06) | 194 | 160 | 0.94 (0.70–1.25) | 0.86 (0.60–1.23) | 32 | 157 | 0.80 (0.48–1.34) | 37 | 154 | 0.92 (0.56–1.51) |
| >1.76 | 146 | 173 | 0.99 (0.72–1.36) | 201 | 163 | 0.96 (0.72–1.28) | 1.01 (0.71–1.44) | 44 | 160 | 1.08 (0.66–1.76) | 37 | 152 | 0.94 (0.57–1.57) |
| P trendc | 0.73 | 0.73 | 0.92 | 0.89 | 0.78 | ||||||||
| P hetd | 0.98 | 0.77 | |||||||||||
| Triclosan | |||||||||||||
| ≤ 5.27 | 136 | 173 | 1.00 | 261 | 166 | 1.00 | 1.00 | 41 | 150 | 1.00 | 52 | 157 | 1.00 |
| 5.27– ≤20.57 | 115 | 162 | 0.89 (0.64–1.23) | 182 | 179 | 0.65 (0.49–0.87) | 0.71 (0.50–1.02) | 29 | 169 | 0.61 (0.36–1.03) | 38 | 148 | 0.82 (0.51–1.33) |
| >20.57 | 155 | 194 | 0.98 (0.72–1.35) | 183 | 156 | 0.76 (0.56–1.02) | 0.78 (0.54–1.11) | 46 | 156 | 1.03 (0.63–1.69) | 27 | 166 | 0.56 (0.33–0.95) |
| P trendc | 0.85 | 0.02 | 0.11 | 0.91 | 0.04 | ||||||||
| P hetd | 0.16 | 0.17 | |||||||||||
| Total Parabens | |||||||||||||
| ≤ 49.26 | 118 | 136 | 1.00 | 277 | 203 | 1.00 | 1.00 | 35 | 145 | 1.00 | 46 | 163 | 1.00 |
| 49.26 ≤201.53 | 133 | 182 | 0.80 (0.57–1.12) | 205 | 158 | 0.95 (0.72–1.26) | 1.06 (0.74–1.50) | 39 | 158 | 1.06 (0.63–1.78) | 43 | 153 | 1.07 0.66–1.72) |
| >201.53 | 155 | 211 | 0.78 (0.56–1.09) | 144 | 140 | 0.75 (0.55–1.02) | 0.89 (0.61–1.30) | 42 | 172 | 1.07 (0.63–1.84) | 28 | 155 | 0.72 (0.42–1.23) |
| P trendc | 0.14 | 0.10 | 0.65 | 0.80 | 0.34 | ||||||||
| P hetd | 0.96 | 0.40 | |||||||||||
Unconditional logistic regression stratified by BMI or WHR and adjusted for education, number of children, age at menarche, menopausal status at urine collection, neighborhood socioeconomic status at urine collection, smoking at urine collection, alcohol intake, and Mediterranean energy adjusted total score. Missing categories of covariates were included in the analyses
Waist hip ratio(WHR) information was collected at the third follow-up questionnaire (2003–2006); we included subjects with WHR information before breast cancer diagnosis and for all control women.
P trend (log analyte) df=1
P heterogeneity for BMI (≤25 vs >25 kg/m2) or for WHR (≤0.854 vs >0.854)