TABLE 3.

Nine hub genes and their functions.

Gene symbol	Description	Function
CXCL8	Chemokine (C-X-C motif) Ligand 8	attracts neutrophils, basophils, and T-cells, involving in neutrophil activation
ICAM1	Intercellular Adhesion Molecule 1	Encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system.
CXCR4	Chemokine (C-X-C motif) Receptor 4	A role in regulation of cell migration
CD44	CD44 Molecule	lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis
IL1B	Interleukin 1 Beta	Potent proinflammatory cytokine
MMP9	Matrix Metallopeptidase 9	Involving in the breakdown of extracellular matrix in normal physiological processes and disease processes.
SPP1	Secreted Phosphoprotein 1	A cytokine involved in enhancing production of interferon-gamma and IL-12 and reducing production of IL-10 and is essential in the pathway that leads to type I immunity.
TIMP1	TIMP Metallopeptidase Inhibitor 1	Metalloproteinase inhibitor forming one to one complexes with target metalloproteinases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.
HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	A master transcriptional regulator of the adaptive response to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease.