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. Author manuscript; available in PMC: 2022 Jun 16.
Published in final edited form as: ALTEX. 2020 Apr 30;37(4):579–606. doi: 10.14573/altex.1912181

Fig. 7: Scheme for the identification of possible source substances in a RAx approach.

Fig. 7:

Given the target substance T, possible source substances are (i) substances producing the same metabolite M (parent substance P) but also (ii) the metabolite itself (target metabolite M). This pattern can be confirmed if other substances present the same trend in a category, where substances A1, A2, etc. (iii) metabolize to give metabolite M1, M2, etc., which can also be grouped together (iv). Availability of existing in vivo studies may be random in such a scheme. Nevertheless, they may predict the possible effect of target substance T with a high level of confidence.