Key resources table

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Bacterial and virus strains
CmpX13 cells	(Mathes et al., 2009)	N/A
Chemicals, peptides, and recombinant proteins
heat-inactivated Fetal Bovine Serum	Sigma	Cat# F4135
Schneider’s Drosophila Medium	ThermoFisher	Cat# 21720024
Effectene reagent	Qiagen	Cat# 301425
TransIT-Insect Transfection Reagent	Mirus	Cat# MIR6100
Schneider’s Drosophila Medium	ThermoFisher	Cat# 21720024
SNAP-Cell 647-SiR	New England Biolabs	Cat# S9102S
SNAP-Cell 505-Star	New England Biolabs	Cat# S9103S
CLIP-Cell 505	New England Biolabs	Cat# S9217S
CLIP-Cell 505	New England Biolabs	Cat# S9217S
gradient stain-free gel	BioRad	Cat# 4568095
magnetic HA resin	ThermoFisher	Cat# 88836
Strep-Tactin resin	IBA	Cat# 2–1208-025
Experimental models: Cell lines
Drosophila S2 cell	ATCC	CRL-1963
Software and algorithms
NEBuilder	New England Biolabs	https://nebuilder.neb.com/
NEBaseChanger	New England Biolabs	https://nebasechanger.neb.com
image lab	BioRad	https://www.bio-rad.com/en-us/product/image-lab-software?ID=KRE6P5E8Z
DD version 7B	(Stein et al., 2015)	https://lab.vanderbilt.edu/hustedt-lab/dd/
MD simulations	(Ganguly et al., 2016)	N/A
Singluar Value Decomposition (SVD) method	(Srivastava and Freed, 2019)	https://denoising.cornell.edu/
Other
Chemidoc imaging system	BioRad	https://www.bio-rad.com/en-us/product/chemidoc-imaging-system?ID=OI91XQ15
Superdex 200 Size Exclusion Column (10/300 GL)	GE Healthcare	Cat# 28990944
Bruker E500 spectrometer equipped with a super Hi-Q resonator	Bruker	E500
Bruker E580 spectrometer equipped with a 10 W solid-state amplifier	Bruker	E580
EN 5107D2 Cavity with a cryogen-free insert/temperature controller	Bruker	EN 5107D2
UV/Vis spectrophotometer	Agilent	Cat# 8534
blue laser	World Star Tech	TECBL-440
Recombinant DNA	Listed in supplementary	N/A