Table 2.

Key topics covered by week in the 2020 MEDI 501 course

Week	Topics	Generalizable TS principles
Week 1	•  Introduction to translational science •  Overview of the case study from drug discovery to development •  Description of how the metarrestin project was initiated	•  Address unmet patient needs •  Take evidence-informed risks •  Pursue major research breakthroughs rather than incremental advances •  Use boundary-crossing partnerships
Week 2	•  Organizational approaches to enable and optimize effective team-based translational research, innovation, and risk-taking •  Creativity and innovation, and evidence-informed risk-taking: phenotypic-based drug discovery approaches and high-throughput screening •  Optimizing clinical predictability to accelerate research: in vitro assays for drug discovery and development	•  Pursue creativity and innovation •  Take evidence-informed risks •  Produce cross-cutting solutions •  Leverage cross-disciplinary team science •  Enhance the efficiency and speed of translational research
Week 3	•  Cross-disciplinary collaboration with medicinal chemistry to advance preclinical translation research •  Optimize medicinal chemistry contributions to advance from drug discovery to drug development	•  Leverage cross-disciplinary team science •  Enhance the efficiency and speed of translational research
Week 4	•  Approaches for successful cross-agency partnerships (government, academia, and industry), including protecting intellectual property and leveraging legal agreements •  Strategies for successful cross-disciplinary team-based science for individuals, teams, and organizations	•  Use boundary-crossing partnerships •  Leverage cross-disciplinary team science
Week 5	•  Aligning animal models with clinical needs to enhance research quality and efficiency •  Cross-disciplinary collaboration with pharmacology and toxicology to transition from drug discovery to studies that enable filing for an Investigational New Drug (IND) •  Addressing unmet patient needs: focus on metastatic pancreatic cancer	•  Address unmet research and patient needs •  Leverage cross-disciplinary team science •  Enhance the efficiency and speed of translational research
Week 6	•  Innovation in preclinical translational research: moving from phenotypically driven studies to target identification	•  Pursue creativity and innovation •  Enhance the efficiency and speed of translational research
Week 7	•  Regulated clinical trials – goals, design, and implementation •  Advancing to first in human clinical trials •  Wrap up: case study overview from phenotypic observation to drug development and testing, conclusions, and additional resources	•  Produce cross-cutting solutions •  Review all principles demonstrated in this case