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Safety of nicotine vaccines on mice. The body weight of the mice was monitored throughout the study, and the mice that received either the PBS buffer or nicotine vaccines were sacrificed on day 120. The major organs of mice, including heart, liver, spleen, lung, kidney, and stomach were harvested for a safety study. (A) Body weight of mice. (B) H&E staining of the sections of mice organs. Scale bars represent 200 μm.
