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. 2022 Jun 16;10:goac028. doi: 10.1093/gastro/goac028

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© The Author(s) 2022. Published by Oxford University Press and Sixth Affiliated Hospital of Sun Yat-sen University

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Mitochondrial alterations after jet lag. (A) Representative mitochondrial morphological changes were detected using transmission electron microscopy (six mice per group). (B) Western blot analysis of Drp1 and p-Drp1 at ZT4 and ZT16 (six mice per group). (C) The relative expression of Drp1 and p-Drp1 normalized with Vdac (six mice per group). (D) Photomicrograph of mice colon tissue immunohistochemical analysis for Ki67. (E) Qualification of Ki67-positive staining area (six mice per group). The values are expressed as mean ± SD. *P < 0.05 vs control mice at individual time points (t-test). ZT, zeitgeber time; DDS, dextran sodium sulfate.