Fig. 1. Study design.
Twelve DIA/DIG tumours were identified by a retrospective data search and pathological review. High-grade and low-grade areas were identified and microdissected. DNA was extracted for whole exome sequencing (WES) and EPIC methylation array (850k) analysis, and RNA was extracted for total RNA sequencing (RNA-seq). CNV: copy number variation; DMP: differentially methylated probe; DMR: differentially methylated region; indel: insertion or deletion; SNV: single-nucleotide variation.