Table 2. Pharmacokinetic Parameters of Tacrine and Hydroxytacrine after Oral Administration of Tacrine Alone (Group III) and Intravenous Administration of Pinocembrin Followed by Oral Administration of Tacrine (Group IV) in Rats^a.

	tacrine		hydroxytacrine
pharmacokinetic parameters	group III (alone)	group IV (with pinocembrin)	group III (alone)	group IV (with pinocembrin)
Cmax (ng/mL)	84 ± 16	227 ± 63	499 ± 126	450 ± 170
Tmax (h)	1.2 ± 0.4	0.5 ± 0.0	1.3 ± 0.3	0.8 ± 0.3
AUC0–t (ng·h/mL)	142 ± 13	297 ± 52*	907 ± 129	763 ± 88
AUC0–∞ (ng·h/mL)	152 ± 13	308 ± 54*	936 ± 135	808 ± 86
T1/2 (h)	1.7 ± 0.2	1.8 ± 0.5	1.5 ± 0.3	1.6 ± 0.6
Vd/F (L/kg)	66.2 ± 7.5	38.1 ± 10.5
Cl/F (L/h/kg)	27.1 ± 2.1	15.8 ± 4.1*

^aData are presented as the mean ± SEM (n = 5). *p < 0.05 denotes statistical significance when compared between group III versus group IV.