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. 2022 Jun 16;14:65. doi: 10.1186/s13073-022-01068-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Candidate genes in genomic regions recurrently affected by focused amplifications or deletions. A GISTIC scores (y-axis) per chromosome (x-axis) for combined dataset of acral and mucosal melanomas. Recurrently (q-values < 0.1) amplified regions are colored red and recurrently deleted regions are colored blue, with relevant oncogenes and tumor suppressors labeled. Putative melanoma driver genes are marked in parentheses. B, C Minimally amplified regions (indicated in vertical lines) for amplifications of chromosome 5 with candidate genes. The filled circles on the left side indicate mucosal melanomas, with unlabeled cases representing acral melanomas. For panel B, the amplified region is shown at two different resolutions