Table 3.
Hazard ratios and 95% confidence intervals of the duration of hormone therapy on the diagnosis of dementia
| All dementia | Alzheimer’s disease | Vascular dementia | ||||
|---|---|---|---|---|---|---|
| Crude | Adjusteda | Crude | Adjusteda | Crude | Adjusteda | |
| Hazard ratio (95% confidence interval) | ||||||
| Duration of OC use (years) | ||||||
| Never | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| < 1 | 0.71 (0.68, 0.74) | 0.92 (0.88, 0.96) | 0.71 (0.67, 0.74) | 0.92 (0.88, 0.97) | 0.76 (0.66, 0.87) | 0.96 (0.84, 1.10) |
| ≥ 1 | 0.78 (0.74, 0.82) | 0.90 (0.86, 0.95) | 0.77 (0.73, 0.81) | 0.89 (0.84, 0.94) | 0.87 (0.75, 1.01) | 0.97 (0.84, 1.13) |
| Duration of HRT (years) | ||||||
| Never | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| < 2 | 0.43 (0.41, 0.45) | 0.84 (0.80, 0.88) | 0.43 (0.40, 0.45) | 0.84 (0.79, 0.89) | 0.44 (0.38, 0.51) | 0.82 (0.71, 0.96) |
| 2–5 | 0.40 (0.37, 0.43) | 0.80 (0.74, 0.86) | 0.39 (0.36, 0.43) | 0.80 (0.74, 0.88) | 0.42 (0.33, 0.53) | 0.81 (0.64, 1.02) |
| ≥ 5 | 0.48 (0.45, 0.52) | 0.78 (0.72, 0.84) | 0.48 (0.44, 0.52) | 0.78 (0.71, 0.85) | 0.39 (0.30, 0.51) | 0.61 (0.47, 0.79) |
Abbreviations: OC oral contraceptives, HRT hormone replacement therapy
aAdjusted for age, body mass index, level of income, current smoking, drinking status, regular exercise, diabetes mellitus, hypertension, and dyslipidemia