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. 2022 Jun 1;7(23):19243–19260. doi: 10.1021/acsomega.2c00518

Table 5. Screened Drugs Irbesartan, Ambenonium, Sulfinpyrazone, Forasartan, Tasosartan, Pranlukast and Gene Interactions.

  genes interaction scores functions/diseases references
irbesartan AGTR1 1.76 osteosarcoma of bone; childhood osteosarcoma; osteoarthritis (114, 115)
SLC10A1 4.73 hepatitis B (119)
AGT 1.11 childhood osteosarcoma (41)
EDN1 0.79 carcinogenesis (120)
APOB 0.5 carcinogenesis (121)
APOE 0.47 Alzheimer’s Disease (122)
ACE 0.2 osteoporosis (123)
JUN 0.3 osteosarcoma (124)
SLC2A4 0.22 osteosarcoma of bone; childhood osteosarcoma (125)
CYP2C9 0.04 ankylosing spondylitis (126)
ambenonium ACHE 9.19 Alzheimer’s disease (113)
sulfinpyrazone SLC22A12 2.37 renal hypouricemia (127)
ABCC1 0.88 Ewing’s sarcoma of bone osteosarcoma of bone; childhood osteosarcoma (87, 88)
ABCC2 0.79 sarcoma, fibrosarcoma (86)
FPR1 0.59 carcinogenesis (128)
UGT1A9 0.5 carcinoma (129)
NR1I2 0.1 osteosarcoma of bone; adolescent idiopathic scoliosis (110, 111)
CYP3A4 0.02 osteosarcoma (96)
VDR 0.01 osteoporosis (130)
HPGD 0.02 carcinogenesis (131)
forasartan AGTR1 8.91 osteosarcoma of bone; childhood osteosarcoma; osteoarthritis, knee (114, 115)
tasosartan AGTR1 5.01 osteosarcoma of bone; childhood osteosarcoma; osteoarthritis, knee (114, 115)
AGTR2 7.1 hypertensive disease (132)
pranlukast RNASE3 20.29 Ewing’s sarcoma of bone; osteosarcoma of bone; deformity of bone (116118)
CYSLTR1 6.09 carcinogenesis; adenocarcinoma (133)
IL5 6.09 asthma (134)
MUC2 6.09 carcinoma, signet ring cell (135)
CYSLTR2 1.01 carcinogenesis (136)
TNF 0.37 rheumatoid arthritis (137)
NFKB1 0.25 osteosarcoma (138)