Table 2:
Simulation results: average percent of DLT or progression per trial, of patients treated at toxic doses with the proposed CR-CRM design. Simulated trials with targeted maximum toxicity = 25% and N = 35 + 35. (n/a : not applicable)
| Average percent per trial of | ||||||
|---|---|---|---|---|---|---|
| Scenario | MTD | Good | Best | DLT | Progression | Toxic assignment |
| S1 | 3 | 2,3 | 3 | 18 | 41 | 18 |
| S2 | 3 | 1,2,3 | 1,2,3 | 17 | 24 | 14 |
| S3 | 3 | 2,3 | 2,3 | 19 | 26 | 15 |
| S4 | 3 | 2,3 | 3 | 18 | 30 | 15 |
| S5 | 1 | 1 | 1 | 20 | 50 | 20 |
| S6 | 1 | 1 | 1 | 24 | 23 | 17 |
| S7 | 2 | 2 | 2 | 21 | 30 | 18 |
| S8 | 1 | 1 | 1 | 22 | 42 | 20 |
| S9 | 5 | 4,5 | 5 | 15 | 31 | n/a |
| S10 | 5 | 3,4,5 | 3,4,5 | 14 | 28 | n/a |
| S11 | 5 | 5 | 5 | 15 | 37 | n/a |
| S12 | 2 | 2 | 2 | 20 | 35 | 18 |