Figure 4.

Fenofibrate suppressed Th1 and Th17 induction while promoting Treg differentiation. (A–C) CD4⁺ T cells stimulated with anti-CD3 and anti-CD28 mAbs were cultured under Th1 (A), Th17 (B), or Treg (C) polarizing conditions for 3 days in the presence of fenofibrate (2 µM) or a control, respectively. Frequencies of Th1, Th17, and Treg cells were detected by flow cytometry. Data are representative of three independent experiments. Data are shown as mean ± SD (n = 3, Student's t-test, *P < 0.05, **P < 0.01).