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. 2022 May 18;90(6):e00176-22. doi: 10.1128/iai.00176-22

FIG 6.

FIG 6

In vivo assessment of MAb prophylaxis in a lethal systemic model of E. coli disease. (A and B) Six- to 8-week-old female BALB/cJ mice were pretreated with 10 mg/kg (A) or 25 mg/kg (B) MAb, then inoculated with ~6.5 × 106 CFU of UTI89 E. coli, and monitored for 24 h before euthanasia and enumeration of organ bacterial burdens. Limit of detection (LoD) was 200 CFU/mL. All groups began with 5 mice, and mice that did not recover from anesthesia were excluded and account for any groups with <5 data points. Data were compared to control MAb (rSTAU-228) by Kruskal-Wallis testing with Dunn’s correction for multiple comparisons. No conditions exhibited statistically significant differences. Error bars show standard deviation.