TABLE 2.
Multivariate analysis of factors associated with not following treatment advice (all advisories combined)
| Univariate | Multivariate | |||
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Centre | ||||
| Site A | Reference | Reference | ||
| Site B | 7.44 (3.43–16.14) | 0.001 | 7.54 (3.46–16.41) | 0.001 |
| Site C | 0.46 (0.15–1.44) | 0.184 | 0.37 (0.12–1.18) | 0.094 |
| Site D | 1.31 (0.46–3.74) | 0.609 | 1.80 (0.62–5.29) | 0.282 |
| Site E | 1.94 (0.84–4.49) | 0.119 | 1.57 (0.64–3.86) | 0.322 |
| Site F | 1.57 (0.62–3.97) | 0.341 | 1.01 (0.38–2.69) | 0.987 |
| Other | 2.15 (0.98–4.69) | 0.056 | 1.39 (0.62–3.10) | 0.428 |
| Ethnic minority group | 2.06 (0.95–4.46) | 0.068 | 3.10 (1.68–5.73) | 0.001 |
| Ex-smoker | 1.11 (0.69–1.80) | 0.664 | 1.31 (0.81–2.11) | 0.265 |
| ER visit (prior year) | 0.58 (0.32–1.04) | 0.070 | 0.54 (0.32–0.92) | 0.024 |
| ACQ-7 >1.5 | 0.94 (0.63–1.39) | 0.757 | 1.16 (0.79–1.70) | 0.459 |
| Previous changes | ||||
| 0 | Reference | Reference | ||
| 1 | 1.67 (1.08–2.59) | 0.021 | 1.89 (1.18–3.02) | 0.008 |
| 2+ | 2.07 (1.19–3.62) | 0.010 | 2.77 (1.51–5.10) | 0.001 |
| Treatment adjustment | ||||
| Maintain treatment | Reference | Reference | ||
| Amend ICS/OCS dose | 11.58 (7.05–19.02) | 0.001 | 11.75 (6.97–19.78) | 0.001 |
| Add/remove LAMA | 9.95 (4.82–20.53) | 0.001 | 9.84 (4.20–23.02) | 0.001 |
| Add/remove OCS | 24.36 (13.62–43.58) | 0.001 | 29.28 (16.07–53.36) | 0.001 |
ER: emergency room; ACQ: Asthma Control Questionnaire; OCS: oral corticosteroid; ICS: inhaled corticosteroid; LAMA: long-acting muscarinic antagonist.