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. 2022 Jun 2;13:888612. doi: 10.3389/fimmu.2022.888612

Figure 1.

Figure 1

HAPLN1 is up-regulated in RA patients and positively correlated with AMPK. (A) Increased HAPLN1 expression, quantified by the H score, in RA (n=20) than OA (n=17) synovium (magnification of gross looking, 10×5; magnification of foci in the framed, 10×20). (B) Plasma HAPLN1 levels examined by ELISA were significantly enhanced in RA (n=61) patients than OA (n=20) patients and HC (n=12), while AMPK levels were decreased in both OA and RA patients compared to HC. Plasma HAPLN1 and AMPK levels were significantly positively correlated (r = 0.693, p < 0.0001). (C) Volcano plot showing higher expression of the HAPLN1 gene in FLSs from RA than OA patients (n=3 in each group). (D, E) Plasma HAPLN1 levels negatively correlated with the disease course (r = -0.311, p = 0.038) and showed a moderately positive correlation with RF levels (r = 0.431, p = 0.038) of RA patients. (F, G) No significant correlation between the HAPLN1 level and ESR and CRP. *p < 0.05; **P < 0.01; ***p < 0.001.