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. 2022 Jun 2;13:888612. doi: 10.3389/fimmu.2022.888612

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Copyright © 2022 Chen, Wang, Chen, Wu, Lai, Wei, Nandakumar and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of si-HAPLN1 on RA-FLS activity. Transfection of siHAPLN1 in RA-FLSs did not significantly affect the (A) proliferation but significantly increased (B) apoptosis (magnification: 10×10) and (C, D) migration ability of RA-FLSs. Wound healing (C, magnification: 10×5) and transwell assays (D, magnification: 10×5) were used to measure the migration capacity of FLSs. Recombinant HAPLN1 (50 ng/ml) attenuated the increased migration ability induced by si-HAPLN1 in the transwell assay. *p < 0.05; **p < 0.01; ****p < 0.0001. NC, negative control is control siRNA of si-HAPLN1.