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Transcriptome analysis of rHAPLN1-treated RA-FLSs. (A) Among the 504 DEGs detected, 439 were up-regulated and 65 were down-regulated. (B) Two DEGs detected (up-regulated LRP1 and down-regulated CRIP1) were in accordance with the proteomic studies. (C) Metascape analysis of DEGs demonstrated an enrichment of various pathways including replication fork processing, GTPase cycle, cell cycle, and cell division.
