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. 2022 Jun 2;13:882651. doi: 10.3389/fimmu.2022.882651

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Copyright © 2022 Chen, Liu, Liang, Ye, Huang, Chen, Sun, Yi, Zhou, Jiang, Chen, Li, Chen, Guo, Chen, Yao, Liao, Yu, Wu, Fan, Gan and Zhan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A, B) Venn diagrams were plotted. (A) Cytoscape software calculated the hub 30 key proteins by Closeness, Degree, and MCC methods, respectively. A total of 13 hub proteins were obtained by the intersection of three methods. (B) There were 9 key proteins in the intersection of the hub proteins calculated by Cytoscape and the proteins of the Coronavirus disease-COVID-19 pathway. (C, D) Differential analysis of immune-related genes. (C) 30 immune-related genes include 7 down-regulated genes and 23 up-regulated genes. (D) The circus heatmap clearly showed the clustering of all the immune-related genes in STB tissue and non-TB spinal tissue.