Figure 1. Typical Extent of fMRI Activation to the SD-TD Task Contrast.

(A) Frequency of activations across individual patient maps. Voxels that contained significant activation in <25% of patients are shown in purple; voxels active in 25% to 50% of patients, in red; and voxels active in >50% of patients, in yellow. Activation tended to be left-lateralized in most patients and included areas known to be involved in language and semantic processing. (B) Example activation patterns in 3 individual patients taken from the prediction analysis: the most right and left-lateralized patients in our sample and a patient with representative symmetric activation. Of note, patients with atypical lateralization tend to activate homologous contralateral regions. LI = laterality index; SD-TD = semantic decision–tone decision.