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. 2022 Jun 15;17(1):641–658. doi: 10.1515/biol-2022-0067

Figure 1.

Figure 1

SMF and SAF treatments downregulated FTO gene expression in the hypothalamus. (a) Relative mRNA levels of FTO gene expression in the hypothalamus of baseline, control, and HFD-induced obese animals. (b) Three weeks of SMF and SAF supplementation significantly reduced FTO mRNA levels in the hypothalamus of HFD-induced obese rats. (c) Continued SMF and SAF supplementation to the 6th week further significantly downregulated the FTO mRNA levels in the hypothalamus of HFD-induced obese rats. Data in the graphs 1b, and 1c, are presented as means ± S.E.M compared to the untreated (negative) control (group 2) (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, and ns indicates p > 0.05). All data depicted in the graphs represent three biological repeats.