Table 1. Topics Covered by Our Proposed Problem-Based Learning (PBL) Case on the Four Metabolic Cycles Described by Hans Krebs.

Topics covered	Number of guide tasks per topic
Historical issues regarding the scientific work made by Sir Hans Krebs	6
On the structure and properties of some molecules involved in Krebs’ cycles and the topology of these cycles	10
On the four metabolic cycles described by Krebs, their regulation, and their metabolic integration	21
On diseases linked to a bad functioning of the Krebs’ cycles	9