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. Author manuscript; available in PMC: 2022 Jul 13.
Published in final edited form as: Dev Cell. 2021 Dec 21;57(1):112–145.e2. doi: 10.1016/j.devcel.2021.11.007

Figure 6. Immune cells of the human lung.

Figure 6.

(A) Depiction of lung immune cell types featured in CellCards. They can be delineated based on surface protein expression, with all immune cells expressing CD45. Macrophages are CD11b+; dendritic cells are CD11c+; T cells are CD3+ and B cells are CD19+. Specialized T and B cell states can be identified using additional markers. (B) Heatmap shows expression levels of representative marker genes of lung immune cells using single cell RNAseq data (Travaglini, et al., 2020). Both original annotations and Azimuth-projected annotations were used for cell designations (Hao, et al., 2020). IGSF21+ dendritic cells and basophil/mast cells from the original publication were renamed as interstitial macrophages and mast cells based on the transcriptional profile. Cell ontology labels were used to better illustrate identities of cells. Average normalized values (log2(CPM+1)) for each cell type were used in the heatmap.